Promiscuous functions of the prion protein family
نویسندگان
چکیده
Sophie Mouillet-Richard* and Jean-Luc Vilotte 1 Toxicology, Pharmacology, and Cellular Signaling, Institut National de la Santé et de la Recherche Médicale Unité Mixtes de Recherche-S1124, Université Paris Descartes, Paris, France 2 Toxicology, Pharmacology, and Cellular Signaling, Sorbonne Paris Cité, Unité Mixtes de Recherche-S1124, Université Paris Descartes, Paris, France 3 Unité Mixtes de Recherche1313 Génétique Animale et Biologie Intégrative, Institut National de la Recherche Agronomique, Jouy-en-Josas, France *Correspondence: [email protected]
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Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp (-/-)) mice. So far, six types of Prnp (-/-) mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obta...
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